Research Projects


Dates and Titles of Research Studies Reviewed


18th Jan            Adapting and implementing a psychoeducational programme following transient ischaemic attack and minor stroke

18th Jan            East Midlands Applied Research Collaboration: Home-based stroke rehabilitation for survivors of stroke with severe disabilities (HoRSSe study) progress update


30th Nov           National Audit Programme: 2021 Audit of post-acute services

26th Oct            Update on Measuring performance of an Integrated Community Stroke Service model (ICSS)

26th Oct            International Stroke Recovery and Rehabilitation Alliance Milestone 6 defining criteria for Centres of Excellence for Stroke Rehabilitation survey of global experts and stroke survivors and carers

21st Sept          National Stroke Audit update

24th Aug           Developing and Evaluating a Cognitive Stimulation Therapy (CST)  Programme for Stroke

24th Aug           Impact of Covid-19 on home care study

13th July           MACE-ICH - a mannitol trial

29th June          INTERACT 3 International haemorrhage stroke study

18th May           Home-based stroke rehabilitation for survivors of stroke with complex disabilities HoRSSe

20th Jan            Definition and implementation of non-medical interventions after TIA and Minor Stroke

20th Jan            NIHSS-SAH Validation Study for Subarachnoid haemorrhage

20th Jan            Mannitol in Acute Ischaemic Stroke Trial (MAIST) study



18th Nov        Pregnancy and stroke

18th Nov        Home-based stroke rehabilitation for survivors of severe stroke (HoRSS study)

23rd Sept       Improving the mobility of stroke survivors with sight loss

23rd Sept       Enhancing recovery after stroke

23rd Sept       ENOS-2 trial

22nd July        A trial of a drug (semaglutide) in acute stroke

22nd July        Tranexamic acid to reduce death or dependency at 3 months (TICH3)

20th May        Orthotic Intervention following stoke (OTIS)

18th March     Vision project – Patient information sheet and debrief information for NSRPG review

18th March     Benefits of beetroot after stroke (BEET-STROKE)

21st Jan         Improving sight after stroke study


17th Sept       Management and Identification of Dehydration After Stroke (MIDAS)

23rd July        Orthotics after stroke research study

23rd July        Understanding reduced energy after stroke – a digital epidemiology study

21st May        “What is the impact of large scale implementation of stroke Early Supported Discharge? (WISE Study)”?

21st May        Facilitating interdisciplinary team working to promote dignity and independence of stroke survivors in hospital (REVIHR)

21st May        Unmet needs for stroke patients in Malaysia

19th March     Open-source Prosthetics and Assistive Devices OPAD Engineering students presented their projects to design assistive devices

19th March     Promoting / examining the cost efficiency of inpatient stroke rehabilitation

19th March     GRASP Graded Repetitive Arm Supplementary Program: A home – work based program to improve arm and hand function in people living with stroke

19th March     OPTIMISM Project: Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management - feedback on workbooks

22nd Jan        Developing and testing a treatment manual for individually tailored rehabilitation of the stroke-affected arm and hand (PREP2-ARM)

22nd Jan        What are the needs of severe stroke survivors?

20th Nov Early Electrical Stimulation to prevent Complications in the Arm Post-Stroke (ESCAPS2)
20th Nov Identifying and Improving End of Life Care for Stroke in Hospitals, UClan
20th Nov Management and Identification of Dehydration After Stroke (MIDAS), UClan
18th Sept The role of orthotics in stroke rehabilitation
18th Sept Development of assistive devices (collaborative project with engineering)
17th July Assessment and Early Treatment of Post-stroke Spasticity in Care Home Residents Feasibility study (FETCH)
17th July What is the impact of Stroke Early Supported Discharge? WISE study
8th May Prevention Of Dementia and Cognitive impairment After Stroke Trial-2 (PODCAST-2)
8th May Comparing the long term outcomes after stroke (LOTUS)
20th March Falls in Stroke Survivors
20th March STEPS-2 Safety and efficacy of pharyngeal electrical stimulation (PES) for post stroke dysphagia: the STEPS-2 randomised controlled trial
20th March Technology Assisted Stroke Rehabilitation
19th Jan PISCES 2 Clinical Study - Stem Cells in the treatment of people who have had a stroke - ReNeuron
19th Jan Dressing Rehabilitation Evaluation for Stroke Survivors (DRESS) – The DRESS 2 Study

18th Jan Translating the Stroke Drivers Screening Assessment into a tablet based App
18th Jan Investigating the Impact of Adjudication in Stroke Trials
18th Jan Exploring Care Pathways for People with Severe Disabilities after Stroke (CaPSS)
18th Jan Understanding and maximising the psychosocial wellbeing of online peer support forums for stroke survivors and their families and carers
14th March PhD Project: Implementing electrical stimulation for upper limb rehabilitation after stroke
14th March TICH2 Update clinical trial to help stop bleeding after haemorrhagic stroke
14th March OPTIMISM Project: poster and information sheets update
14th March D-VAMS Project update: The development of face-based mood scales suitable for assessing mood in stroke patients who have aphasia
16th May Pilot study: Vision problems after stroke
16th May PhD study: Implementing evidence based rural community stroke services: aspiration or reality? 

19th Sept Rapid Intervention with Glyceryl trinitrate in Hyperacute stroke Trial-3 (RIGHT-3)
19th Sept PhD Study: Brain in Hand - a web-based system that synchronises with a smartphone app
19th Sept Proposed study in Vascular Dementia (r4VaD)
21st Nov Investigating the effect of non-pharmacological cognitive interventions to improve brain network functional connectivity in patients with vascular dementia
21st Nov Cognitive Impairment and Fatigue after Stroke
21st Nov OPTIMISM – Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management
21st Nov Desmopressin for treatment of patients taking Antiplatelet agents with Stroke due to Haemorrhage) DASH

19th January How Stroke Research fits with Stroke Care
19th January Proposed Training Programme for Stroke Research Partnership Group members
19th January Cost Effectiveness of a Stroke Care Pathway
11th May Identifying Needs of Informal Young Carers of Stroke Survivors
11th May Reducing Falls in People with Stroke
11th May Stroke Drivers Screening Assessment (SDSA)
13th July Computer assisted stroke rehabilitation (CASR)
13th July Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management (OPTIMISM)
28th Sept Patient Satisfaction with Community Stroke Rehabilitation Teams
28th Sept Partners in Projects Research Involvement Training for lay members
9th Nov Endothelial progenitor cells: potential biomarkers for diagnosis and prognosis of ischaemic stroke
9th Nov MINIMISE study: Mannitol for reducIng intracerbral oedeMa after StrokE
9th Nov Optimising Psychoeducation for Transient Ischaemic Attack and Minor Stroke Management (OPTIMISM): Information sheets & poster

13th January New @astroke structure and website presentation. No research proposals presented.
January Swallowing: a trial to test a feeding tube with a small electrical device in it that might help people who can't swallow after stroke, by stimulating recovery of swallowing
17th March Vision: a trial to test new ways of measuring and hopefully treating visual problems after stroke
17th March STEMS3 clinical study - G-CSF and PT larger study design proposal
17th March TICH-2
27th May Regaining Confidence after Stroke (RCAS) questionnaires
27th May IV Fluids: A feasibility randomised controlled factorial trial of different intravenous fluid regimes in acute stroke
27th May Stroke Clubs - scoping review update
14th July Virtual reality for risk assessment after stroke
14th July Research to Implement Evidence Based In-Hospital Stroke Rehabilitation (REVIHR)
14th July EM CLAHRC and Academic Health Science Network
22nd Sept Academic Health Science Network
10th Nov D-VAMS (Dynamic Visual Analogue Mood Scales)
10th Nov Behavioural Intervention for Stroke Carers - A research project about psychological support for carers after stroke
10th Nov Development of anti-infective long term urinary catheter i4i NIHR grant
10th Nov COgnitive Management PAthways in Stroke Services (COMPASS)

10th June Microsoft 'Kinect' as a Stroke Rehabilitation tool for Patients suffering from Facial Paralysis.
10th June Behavioural therapy for treating post-stroke depression: a pilot randomised controlled trial
10th June Perception of stroke illness questionnaire
14th October Investigating the organisational structure of stroke clubs, and the benefits that they have for stroke survivors: A scoping review.
14th October Electrical stimulation therapy for treating arm weakness after stroke: a pilot randomised controlled trial.
14th October Leader skills required to run the Regaining Confidence After Stroke course.

30th January Fatigue after Stroke: understanding the nature of the clinical problem and determining factors associated with fatigue
30th January YouCall WeCall: Testing a telephone based, information and support service for mild stroke survivors and their carers
2nd April Training
16th April Right 2
16th April Working with individuals' perceptions of their condition to encourage rehabilitation and recovery following stroke.
6th June Facial Rehabilitation Proposal
30th July Stem cell Trial of recovery EnhanceMent after Intra-Cranial Haemorrhage (STEM-ICH)
30th July Implementation of an evidence based treatment protocol for best practice stroke rehabilitation in a hospital setting
12th Sept Training at Trent Bridge plus feedback from Niki Sprigg
26th Nov Measuring confidence after stroke: Confidence after stroke measures
26th Nov (1) Illness perception questionnaire (IPQ-R)
(2) How people feel about their stroke

February (1) Project Grant Plain English Summary
(2) Optimising the Analysis of Stroke and other vascular Trials in Prevention (OAST-P)
25th July Acceptability of mild hypothermia (cooling) for stroke patients in the UK
25th July Filming for the Campaign

10th May A randomised controlled trial of Tranexamic acid in Intracerebral Haemorrhage (TICH)
10th May Music Therapy in the Acute Stage after Stroke and an evaluation of 'Regaining Confidence after Stroke' Course
22nd Dec Life after stroke for care home residents
22nd Dec Regaining Confidence post stroke: A stroke survivors perspective


6th April An investigation of residual activities of daily living problems following TIA and minor
6th April Reducing the burden of misery after Stroke
6th April Getting out of the House
27th July Development of a Functional Assessment of Apraxia in Stroke Rehabilitation
27th July Patient's perceptions of sensory deficits after stroke
27th July Stem cell Trial of recovery ENhanceMent after Stroke 3 (STEMS 3) - a pilot randomised
trial of G-CSF and therapy in chronic stroke
2009 Dopamine Augmented Rehabilitation in Stroke (DARS)


  • The effect of granulocyte-colony stimulating factor (G-CSF) on function of mobilised bone marrow stem cells in stroke: the 'Stem cell Trial of recovery EnhanceMent after Stroke assessing Functional Ability of mobilised cells' (STEMSFA) pilot study The was not funded and has not been taken any further at the moment
  • Is it possible to perform ambulance-based randomised controlled trials in patients with hyperacute stroke? Assessment of glyceryl trinitrate in lowering blood pressure This study was successful and has been completed, showed that it is possible to do trials in the ambulance, and GTN given to acute stroke patients in the ambulance seemed to improved recovery. A larger study RIGHT-2 is being developed and funding has been applied for. Malcolm has helped with the application for RIGHT-2.
  • Nasogastric Feedling Loop
  • Bid for UK Stroke Research Network
  • A dose escalation study of progesterone in acut ischaemic stroke: the pilot Progesterone Efficacy Stroke Trial (ProgEST)
  • Evaluation of Imaging criteria to identify patients at low or high risk allowing for targeted recommendation of carotid endarterectomy (CEA)
  • Evaluation of virtual reality in stroke rehabilitation
  • Dressing After Stroke
  • Home Visits
  • Outdoor mobility
  • Bid for Stroke CLAHRC
  • Stem cell Trial of recovery EnhanceMent after Stroke 2' (STEMS 2) pilot randomised controlled trial
  • Functional Neuroimaging in Spontaneous Intracerebral Haemorrhage (NISICH)
  • Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS)
  • An investigation of residual activities of daily living problems following TIA and minor stroke
  • Adaptation to Memory Problems following stroke
  • Depression after stroke
  • Investigation of Patient Nominated Expert Stroke Therapists' (IPNEST )
  • Improving the management of blood pressure in acute stroke: the 'Efficacy of Nitric Oxide in Stroke' (ENOS) study
  • Impact of a Specialist Nurse-led Disease Management Program on the rate of secondary preventive intervention in people with a recent transient ischaemic attack
  • Blood pressure and cognition.
  • Memory rehabilitation: the Rehabilitation of Memory in Neurological Disabilities (ReMIND) study.
  • Communication and Low Mood (CALM)
  • Return to Work after Stroke
  • Early Supported Discharge
  • 3 projects Niki Sprigg is leading in which members are involved and are current at 2013
  • 141 First for Stroke: Virtual Reality Facial Exercise Funded. Current 2013. Nottingham Trent University. ON on steering group.
  • Barriers to Early Assessment of TIA and stroke (BEATS) Completed and published. University of Leicester. ON on steering group.
  • Optimising the Analysis of Stroke and other vascular trials in prevention (OAST-P)

H Taylor Jan 2021